As a freshman, Taylor appeared in five games and was a supporting player in Virginia Tech's 2007 ACC Championship Game win over No. 12 Boston College. In 2008, the mobile quarterback led the offense to another conference championship and gave Tech back-to-back ACC titles. With Taylor at the helm, the Hokies defeated No. 18 Boston College in Tampa, Florida. This was Virginia Tech's second of three ranked wins in 2008, and followed Tech's 20–7 victory over No. 12 Cincinnati in the Orange Bowl on January 1, 2009.
In 2009, Taylor's passing game took a major step forward, passing for 2,311 yards and 13 touchdowns. The Hokies capped off another 10-win season that year with a 37–14 win over Tennessee in the 2009 Chick-fil-A Bowl. Taylor passed for 209 yards and ran for a touchdown.
Taylor's career concluded with a standout season in 2010, when he set career highs in passing yards (2,473) and passing touchdowns (24). The Hokies started 0-2 but then reeled off 11 straight wins, including a 44-33 win over No. 20 Florida State in the ACC Championship Game. Taylor passed for three points and ran for one and was named MVP en route to his third ACC Championship.
Taylor retired with a 34-8 record, the most wins by a Virginia Tech starting quarterback. He was second in school history with 7,017 passing yards and 15th in rushing yards with 2,196. His 9,213 total receiving yards are second in school history.
Taylor was drafted by the Baltimore Ravens in 2011 and won the Super Bowl with the team in 2012. In 2015, as the starting quarterback for the Buffalo Bills, Taylor set the franchise record for most rushing yards in a season by a quarterback and became the first Bills quarterback to rush for over 500 yards in a season. After the 2015 season, Taylor was selected to the Pro Bowl. In 13 NFL seasons, Taylor has rushed for 12,135 yards and 65 touchdowns.