Frenkie de Jong injured his ankle again in Sunday's 3-2 win and will miss Barcelona's final six games of the season Clasico The loss against Real Madrid, a source confirmed to ESPN.
De Jong, 26, was sent off just before half-time after scuffling for the ball with Madrid midfielder Federico Valverde.
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The Dutchman will not play again this season, but sources told ESPN he should be able to compete at this summer's European Championship in Germany.
The Netherlands open the tournament against Poland on June 16, followed by matches against France and Austria in the group stage.
This is the third ankle injury this season for De Jong.
He missed 10 games from September to November due to a sprained ankle suffered against Celta Vigo, and a further four games in March with a similar problem.
“The injury was a little bit unfortunate,” De Jong told ESPN before the game. Clasico on friday.
“First someone fell on my ankle and I had a bad ligamentous injury, and then I injured my ankle again.” [in March] That was a big blow. ”
The weekend loss leaves Barça 11 points behind La Liga leaders Madrid with 11 games remaining.
This loss follows their defeat in the Champions League against Paris Saint-Germain in midweek.
The team has already been eliminated in the Spanish Super Cup and the Copa del Rey, and is likely to end the season without a trophy, having surrendered the La Liga title they won last year to Madrid.
However, Barça still need to finish second to secure a place in next season's Super Cup, with the team in third place, two points behind Girona.
Next opponent: Valencia blaugrana On April 29, Xavi Hernández's team concluded the season with matches against Girona, Real Sociedad, Almeria, Rayo Vallecano and Sevilla.
