Anthony Davis had seven points, six rebounds and six blocks to lead the U.S. defense, which held off Serbia throughout the game. Anthony Edwards added 16 points and LeBron James added 11 points.
Curry scored the USA's first nine points, but James said that was part of the plan.
“We painted it for a special reason, to inspire him,” James said. “When you see that ball go through the goal, you see how it impacts the rest of his game and the rest of all of us. He set the tone.”
The U.S. led by as many as 31 points in the final game of a two-match warm-up series in Abu Dhabi, United Arab Emirates. The U.S. plays two more warm-up games in London before heading to France, the first against South Sudan on Saturday and the second against Germany on Monday at the O2 Arena in London.
U.S. coach Steve Kerr praised his team's progress and said their ability to overwhelm opponents with a variety of defensive plays will be key.
“I think our identity as a team is our depth, and our strength is our depth,” Kerr said. “If we can play four or five minutes of intense defense, physicality, rebounding, playing physical, it makes sense to play that way. We'll see if we can continue to do that.”
The U.S. got off to a shaky start but used a 16-2 run in the second quarter to build a 56-42 lead and then led 59-45 at halftime.
Nikola Jokic had 16 points and 11 rebounds for Serbia, and Aleksa Avramovic added 14 points. Serbia was playing its second game in two days, having rested captain Bogdan Bogdanovic in a loss to Australia on Tuesday.
Serbia, without Bogdanovic for the second straight game, struggled offensively, shooting just 41 percent from the field (29 of 71). The U.S. also had a 30-21 rebounding advantage. Adebayo and Davis combined for 14 rebounds.
“The combination of Bam and AD is really awesome,” Kerr said. “It's just a switch, but they can protect the rim and then drop when they get in coverage.”
Wednesday's match was a key prelude for Serbia and the United States, who are both in Group C at the Olympics and will face off on July 28 for the gold medal.
There was no such disappointment this time around for the U.S., who nearly lost a big lead in Monday's narrow win over Australia.
The U.S. led by 25 points at the end of the third quarter and quickly extended that lead to 30 points in the final quarter.
The U.S. fielded a third different starting lineup, featuring Curry, Jrue Holiday, Jayson Tatum, James and Joel Embiid.
The only constants across the three exhibitions were Curry, James and Embiid.
One reason Embiid is on the roster is because U.S. coaches this season wanted to take on a bigger team like Serbia, which features three players who are 7-foot tall.
Embiid is not in top condition yet, but he was effective on both ends of the floor, finding his cutter offensively and being an active deterrent in the lane defensively.
For the second straight game, the U.S. reserves provided a boost. Edwards, Davis, Tyrese Haliburton, Adebayo and Devin Booker all played for the first time with 4:54 left in the first quarter and the team trailing 16-13.
The U.S. went on to outscore Serbia 15-12 and the score was tied at 28-28 going into the second quarter.
The U.S. reserves scored 28 points off the bench in the first half.
Kevin Durant missed his third straight game as he recovers from a calf strain he suffered early in training camp.
But guard Derrick White, who joined the team over the weekend in place of Kawhi Leonard, made his debut and finished with four rebounds and one assist in just over nine minutes of play.
